Trimi vs Sesame
Both clinics sit in our top 10, so this page exists for readers already comparing them here. It is not written for search and is not submitted for indexing. Every figure below is read from the clinic's own page, with the date.
26 of the 51 clinics we rank are an affiliate partner. Scores come only from our published methodology. At equal displayed scores, active affiliate partners are listed first. What it changes is which clinic a promoted button points at, and every such link carries a PICK badge in the table so you can see it before you click.
Says outright that its headline is a monthly equivalent of annual billing, and prints the no-commitment rate beside it instead of leaving you to find it at checkout.
from $99/mo on a 12-month prepaid plan
Verified 2026-09-21
PickA clinician marketplace rather than a clinic. You see who treats you before booking, it dispenses FDA-approved GLP-1s only, and it says outright that medication is billed separately.
from $208/mo combined ($59 care + $149 medication, on a 12-month commitment)
Verified 2026-09-30
Visit →Affiliate link
| Trimi | Sesame | |
|---|---|---|
| Price | from $99/mo on a 12-month prepaid planTheir page, read 2026-09-21 | from $208/mo combined ($59 care + $149 medication, on a 12-month commitment)Their page, read 2026-09-30 |
| Price shape | one-ongoing-rate | membership-excludes-medication |
| What the price doesn’t say | $99/mo is a monthly equivalent of $1,188 billed upfront on a 12-month commitment. Not a month you can pay and stop. With no commitment it is $175/mo. Tirzepatide is $125/mo on the same 12-month basis, or $235/mo with no commitment. | This is two charges added together, not one bill: a care fee plus medication from $149/mo billed separately. Sesame publishes three care fees. $59/mo is care on a 12-month commitment ("*Based on a 12-month Success by Sesame commitment"). $99/mo is care on the Month-to-Month Plan ("Billed every month at $99 per month"), which the same page's billing answer says is "Billed every 28 days", so 13 cycles a year rather than 12. $43/mo appears only on Sesame's medication pages, as "Ongoing care" that "Includes video visits, labs, unlimited chat & more", "From $43 per /mo.", and the page does not explain it: no plan or term is attached, and the same Ozempic page says the subscription "starts as low as $59 per month". We use the $59 and $99 the weight-loss page explains, so the no-commitment floor is $248/mo. |
| What it covers | 12 months of compounded semaglutide, supplies, licensed provider care, ongoing support and free overnight shippingTheir page, read 2026-09-21 | Not published. The page does not say what the figure covers.Their page, read 2026-09-30 |
| Billed on top | Not recorded. We have not found a statement either way.Their page, read 2026-09-21 | The $59/mo care fee excludes medication entirely; medication starts at $149/mo and is billed separately.Their page, read 2026-09-30 |
| Commitment | Committed term. The rate applies on a 12-month prepaid plan. Billed up front on that term. What happens after the first period: Trimi states on the page that the figures shown are monthly equivalents of annual billing, and prints the no-commitment rate ($175/mo semaglutide, $235/mo tirzepatide) next to them.Their page, read 2026-09-21 | Committed term. The rate applies combined ($59 care + $149 medication, on a 12-month commitment). What happens after the first period: Explicit renewal language: "then $349/mo after", plus the billing terms. "Billed every month at $99 per month", "Billed every 3 months", "Billed every 6 months". (Read at source 2026-09-18.).Their page, read 2026-09-30 |
| Routes | compounded semaglutide, compounded tirzepatide | brand-name GLP-1 injection, brand-name oral GLP-1 |
| Score | 7.9 | 6.6 |
What one does that the other doesn’t
Trimi
Offers semaglutide, tirzepatide where Sesame does not.
Sesame
Offers oral/sublingual, brand-name, glp-1 (molecule unnamed) where Trimi does not.
Who each one suits
Every line below is a difference we can measure, with the field or criterion it comes from. Where a side is empty, nothing in what we record favours it. We would rather say that than invent a reason.
Trimi
- Lower published entry figure of the two.Basis: published entry price, each in its own billing unit
- Only one of the two offering: semaglutide, tirzepatide.Basis: published treatments, by drug and route
- Scores clearly higher on transparency (9.0 vs 6.0).Basis: our published scoring rubric
- Scores clearly higher on pricing (8.5 vs 6.5).Basis: our published scoring rubric
Sesame
- Only one of the two offering: oral/sublingual, brand-name, glp-1 (molecule unnamed).Basis: published treatments, by drug and route